The following clubs have regular meetings:
- American Association of Retired Persons
- American Legion
- Azalea Garden Club
- Boy Scouts of America
- Brotherhood of Railroad Signalmen
- F.M.
- Girl Scouts of U.S.A.
- Good Shepherd Riding Academy, Inc.
- Greenville Lions Club
- Greenville Masonic Lodge
- Junior Woman’s Club
- Manchester Business Association, Inc.
- Manchester Kiwanis Club
- Manchester Lions Club
- Manchester Woman’s Club
- Manchester-Warm Springs Pilot Club
- Meriwether 4-H Program
- Meriwether County Cattlemen’s Association
- Meriwether County Chamber of Commerce
- Meriwether County Division of the American Heart Association
- Meriwether County Historical Society
- Meriwether County Kiwanis Club
- Meriwether County LaLeche League
- Order of the Eastern Star
- People Assisting the Handicapped (P.A.T.H.) in Meriwether County
- Partners Advancing in Community
- Retired Teachers of Meriwether County
- Rotary Club of Meriwether Count
- Senior Citizens Club
- Stephens Lodge Number 586
- United Trainmen Auxiliary
- Veterans of Foreign Wars
- Warm Springs Area Tourism Association
Churches
Most major denominations have houses of worship in Meriwether County:
- Assemblies of God
- Baptist
- Catholic
- Church of God
- Church of Jesus Christ
- Congregational Christian
- Evangelical
- Holiness
- Jehovah Witness
- Methodist
- Missionary Baptist
- Nazarene
- Presbyterian
- Seventh-Day Adventist
- Southern Baptist
- United Methodist